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The best designing solution of bone marrow transplantation “BMT” units: a story survey

Updated: Oct 9

Date: ( 5 / 10 /2022)

GI: General Information

DOI: Direction of information

Foundation: Patients going through bone marrow transplantation or chemotherapy for disease are significantly immunosuppressed. They are in danger for both endogenous and exogenous contaminations and require improved assurance from disease while in emergency clinic.

Targets: The point of this account audit was to decide the ideal plan elements of bone marrow relocate (BMT) units for diminishing disease risk in these weak patients.


Sources: A writing search was performed on PubMed and different data sets for records distributed between January 2000 and October 2021. Keywords were: hematopoietic stem cell transplant unit OR bone marrow transplant unit OR hematology unit OR HEPA filtration OR ALPA filters OR haemato-oncology unit AND design OR design guidelines OR design criteria OR ventilation specification OR water outbreaks.

Content: Guidelines and different papers relating to BMT unit configuration are talked about. Key plan highlights distinguished from the writing to control contamination gambles and reduce infection risk incorporate high effectiveness particulate air filtration, positive-pressure ventilation, adequate air changes and clean rooms. The proof for every one of these parameters and different discoveries are examined. We tracked down no rules well defined for water quality and control in BMT units.

Suggestions: Guidelines on the different parts of configuration were found, however no exhaustive direction records tending to every single significant viewpoint, like ventilation, water, and other Design highlights, were found. Artistic distributions and strategy records were consolidated and summed up to feature key design highlights pointed toward reducing infection risk in this vulnerable patient gathering. We propose the improvement of international guidance for the design of BMT units incorporating all parts.

Keywords: Blood and Marrow Transplant; BMT; Airborne; Bone marrow transplant unit; Air sanitization; Infection control; Decontamination; Healthcare environment; Immunosuppression; Ventilation; WHO; CDC; ASHRAE; FACT; JACIE; GMP; ISO; EBMT; Sterilization by filtration and aseptic processing; Steam sterilization; Sterile filtration.


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